Images from Research Papers


Schematic representation of a funneled energy landscape. (Wolynes, Phil. Trans. R. Soc. A, 2005 [link])

Free energy profiles of two-state (top) and downhill (bottom) folding mechanisms. (Cho, Weinkam, Wolynes, Proc. Natl. Acad. Sci., 2008 [link])

Protein structures in a funneled energy landscape with order parameter Q and Pfold shown. (Cho, Levy, Wolynes, Proc. Natl. Acad. Sci., 2006 [link])

Dual funneled energy landscape of Rop dimer. (Levy, Cho, Shen, Onuchic, Wolynes, Proc. Natl. Acad. Sci., 2005 [link])

Sequential folding of foldons in a funneled energy landscape. (Weinkam, Zong, Wolynes, Proc. Natl. Acad. Sci., 2005 [link])

A blind prediction of a protein structure using an optimized associative memory energy function. (Wolynes, Phil. Trans. R. Soc. A, 2005 [link])

Hypothetical minimal folding nucleus of ankyrin repeating proteins. (Ferreiro, Cho, Komives, Wolynes, J. Mol. Biol., 2005 [link])

Schematic of a protein imbedded in a vitrified solvent. (Lubchenko, Wolynes, Frauenfelder, J. Phys. Chem. B, 2005 [link])

The folding mechanism of tetrameric p53 as a "dimer of dimers". (Levy, Cho, Onuchic, Wolynes, J. Mol. Biol., 2005 [link])

Water-mediated interactions in protein folding. (Papoian, Ulander, Eastwood, Luthey-Schulten, Wolynes, Proc. Natl. Acad. Sci., 2004 [link])

Residue strain energy of adenylate kinase structures along nonlinear conformational change path that induces local unfolding, or "cracking". (Miyashita, Onuchic, Wolynes, Proc. Natl. Acad. Sci., 2003 [link])

A cartoon of how the "fly-casting mechanism" increases folding speed because the increased capture radius allows the unfolded protein to find its specific binding site faster. (Shoemaker, Portman, Wolynes, Proc. Natl. Acad. Sci., 2000 [link])